Gong Ruining, Jiang Yueping
Department of Gastroenterology, Affiliated Hospital of Qingdao University, Qingdao, China.
Front Oncol. 2020 Mar 17;10:309. doi: 10.3389/fonc.2020.00309. eCollection 2020.
Non-coding RNAs (ncRNAs) are reported to be expressed in human cancers, including pancreatic ductal adenocarcinoma (PDAC). These ncRNAs affect the growth, migration and invasion of tumor cells by regulating cell cycle and apoptosis, as well as playing important roles in epigenetic processes, transcription and post-transcriptional regulation. It is still unclear whether alterations in ncRNAs influence PDAC development and progression. Because of this, analysis based on existing data on ncRNAs, which are crucial for modulating pancreatic tumorigenesis, will be important for future research on PDAC. Here, we summarize ncRNAs with tumor-promoting functions: HOTAIR, HOTTIP, MALAT1, lncRNA H19, lncRNA PVT1, circ-RNA ciRS-7, circ-0030235, circ-RNA_100782, circ-LDLRAD3, circ-0007534, circRHOT1, circZMYM2, circ-IARS, circ-RNA PDE8A, miR-21, miR-155, miR-221/222, miR-196b, miR-10a. While others including GAS5, MEG3, and lncRNA ENST00000480739, has_circ_0001649, miR-34a, miR-100, miR-217, miR-143 inhibit the proliferation and invasion of PDAC. Hence, we summarize the functions of ncRNAs in the occurrence, development and metastasis of PDAC, with the goal to provide guidance in the clinical diagnosis and treatment of PDAC.
据报道，非编码RNA（ncRNAs）在包括胰腺导管腺癌（PDAC）在内的人类癌症中表达。这些ncRNAs通过调节细胞周期和细胞凋亡来影响肿瘤细胞的生长、迁移和侵袭，并且在表观遗传过程、转录和转录后调控中发挥重要作用。ncRNAs的改变是否影响PDAC的发生和进展仍不清楚。因此，基于现有的对调节胰腺肿瘤发生至关重要的ncRNAs数据进行分析，对于未来PDAC的研究将具有重要意义。在此，我们总结具有促肿瘤功能的ncRNAs：HOTAIR、HOTTIP、MALAT1、lncRNA H19、lncRNA PVT1、circ-RNA ciRS-7、circ-0030235、circ-RNA_100782、circ-LDLRAD3、circ-0007534、circRHOT1、circZMYM2、circ-IARS、circ-RNA PDE8A、miR-21、miR-155、miR-221/222、miR-196b、miR-10a。而其他一些ncRNAs，包括GAS5、MEG3和lncRNA ENST00000480739、has_circ_0001649、miR-34a、miR-100、miR-217、miR-143则抑制PDAC的增殖和侵袭。因此，我们总结了ncRNAs在PDAC发生、发展和转移中的功能，旨在为PDAC的临床诊断和治疗提供指导。
