长链非编码 RNA：在胰腺癌中的作用和贡献。
Long noncoding RNAs: role and contribution in pancreatic cancer.
机构信息
Department of Biotechnology, School of Bioengineering, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Tamil Nadu, India.
Department of Industrial Biotechnology, Sri Venkateswara College of Engineering, Chennai, India.
出版信息
Transcription. 2021 Feb;12(1):12-27. doi: 10.1080/21541264.2021.1922071. Epub 2021 May 26.
Noncoding RNAs are proclaimed to be expressed in various cancer types and one such type is found to be pancreatic ductal adenocarcinoma (PDAC). The long noncoding RNAs (LncRNAs) affect the migration, invasion, and growth of tumor cells by playing important roles in the process of epigenesis, post-transcription, and transcriptional regulation along with the maintenance of apoptosis and cell cycle. It is quite subtle whether the alterations in lncRNAs would impact PDAC progression and development. This review throws a spotlight on the lncRNAs associated with tumor functions: MALAT-1, HOTAIR, HOXA13, H19, LINC01559, LINC00460, SNHG14, SNHG16, DLX6-AS1, MSC-AS1, ABHD11-AS1, DUXAP8, DANCR, XIST, DLEU2, etc. are upregulated lncRNAs whereas GAS5, HMlincRNA717, MIAT, LINC01111, lncRNA KCNK15-AS1, etc. are downregulated lncRNAs inhibiting the invasion and progression of PDAC. These data provided helps in the assessment of lncRNAs in the development, metastasis, and occurrence of PDAC and also play a vital role in the evolution of biomarkers and therapeutic agents for the treatment of PDAC.
非编码 RNA 被宣布在各种癌症类型中表达，其中一种是胰腺导管腺癌 (PDAC)。长链非编码 RNA (LncRNAs) 通过在表观遗传、转录后和转录调控以及维持细胞凋亡和细胞周期过程中发挥重要作用，影响肿瘤细胞的迁移、侵袭和生长。lncRNAs 的改变是否会影响 PDAC 的进展和发展还不太清楚。这篇综述重点介绍了与肿瘤功能相关的 lncRNAs：MALAT-1、HOTAIR、HOXA13、H19、LINC01559、LINC00460、SNHG14、SNHG16、DLX6-AS1、MSC-AS1、ABHD11-AS1、DUXAP8、DANCR、XIST、DLEU2 等上调的 lncRNAs，而 GAS5、HMlincRNA717、MIAT、LINC01111、lncRNA KCNK15-AS1 等下调的 lncRNAs 则抑制 PDAC 的侵袭和进展。这些数据有助于评估 lncRNAs 在 PDAC 的发生、转移和发生中的作用，并在生物标志物和治疗药物治疗 PDAC 的演变中发挥重要作用。
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