死海气候疗法对银屑病的影响；一项前瞻性队列研究。
Effect of Dead Sea Climatotherapy on Psoriasis; A Prospective Cohort Study.
作者信息
Emmanuel Thomas, Lybæk Dorte, Johansen Claus, Iversen Lars
机构信息
Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark.
出版信息
Front Med (Lausanne). 2020 Mar 18;7:83. doi: 10.3389/fmed.2020.00083. eCollection 2020.
Dead Sea climatotherapy (DSC) is a treatment option for psoriasis in Denmark. However, the response to DSC has not been particularly well studied. We sought to determine effectiveness and response duration of DSC on psoriasis-related outcome parameters. Eighteen patients participated in a 4-week treatment program in Ein Gedi in Israel. Treatment, consisting of sun exposure and bathing, was individualized. DSC was associated with a mean 13.0-point reduction (88%) in Psoriasis Area and Severity Index and a mean reduction of 2.3 (76.7%) on the 5-point Investigator's Global Assessment Scale. Furthermore, patients' quality of life improved measured by the Dermatology Quality of Life Index and EuroQol 5D index values. The mean time from treatment end to reappearance of visible skin symptoms was 93.8 days (SD: 62.5, range: 31-219 days). Our results confirm that DSC has an immediate effect on skin manifestations and improves quality of life, but long-term disease control is not observed.
死海气候疗法（DSC）是丹麦治疗银屑病的一种选择。然而，对DSC的反应尚未得到特别充分的研究。我们试图确定DSC对银屑病相关结局参数的有效性和反应持续时间。18名患者参加了在以色列恩盖迪进行的为期4周的治疗项目。治疗包括阳光照射和沐浴，是个性化的。DSC与银屑病面积和严重程度指数平均降低13.0分（88%）以及在5分制研究者整体评估量表上平均降低2.3分（76.7%）相关。此外，通过皮肤病生活质量指数和欧洲五维健康量表指数值衡量，患者的生活质量得到改善。从治疗结束到可见皮肤症状再次出现的平均时间为93.8天（标准差：62.5，范围：31 - 219天）。我们的结果证实，DSC对皮肤表现有即时效果并改善生活质量，但未观察到长期疾病控制效果。
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