Shipley Lindsey C, Singal Ashwani K
Division of Internal Medicine, University of Alabama, Birmingham, AL, USA.
Division of Gastroenterology and Hepatology, University of South Dakota, Avera McKennan University Health Center and Transplant Institute, Sioux Falls, SD, USA.
Transl Gastroenterol Hepatol. 2020 Apr 5;5:26. doi: 10.21037/tgh.2019.11.17. eCollection 2020.
Alcoholic hepatitis (AH) is associated with a high short-term mortality. Currently, most transplant centers require minimum six months of abstinence from alcohol use before considering liver transplant for patients with end stage liver disease. Some recent data are emerging on the benefits and safety of early liver transplantation for patients with severe AH, a population who cannot meet the minimum six months sobriety. This article reviews the current status, benefits, challenges, barriers, and future prospects on early liver transplantation in patients with severe, acute AH.
酒精性肝炎(AH)与短期高死亡率相关。目前,大多数移植中心要求终末期肝病患者在考虑肝移植前至少戒酒六个月。最近有一些关于严重AH患者早期肝移植的益处和安全性的数据出现,这部分患者无法达到戒酒六个月的最低要求。本文综述了严重急性AH患者早期肝移植的现状、益处、挑战、障碍及未来前景。