Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.
Bio-Organic Chemistry, Eindhoven University of Technology, P.O. Box 513 (STO 3.31), 5600 MB Eindhoven, The Netherlands.
Org Biomol Chem. 2020 May 6;18(17):3203-3215. doi: 10.1039/d0ob00464b.
The therapeutic effects of molecules produced by the plant species Cannabis sativa have since their discovery captured the interest of scientists and society, and have spurred the development of a multidisciplinary scientific field with contributions from biologists, medical specialists and chemists. Decades after the first isolation of some of the most bioactive tetrahydrocannabinols, current research is mostly dedicated to exploiting the chemical versatility of this relevant compound class with regard to its therapeutic potential. This review will primarily focus on synthetic pathways utilised for the synthesis of tetrahydrocannabinols and derivatives thereof, including chiral pool-based and asymmetric chemo- and biocatalytic approaches.
自从发现大麻属植物物种产生的分子具有治疗效果以来，它们引起了科学家和社会的兴趣，并促使生物学家、医学专家和化学家等多学科领域的发展。在首次分离出一些最具生物活性的四氢大麻酚几十年后，目前的研究主要致力于利用该相关化合物类别的化学多功能性来挖掘其治疗潜力。本文主要综述了用于四氢大麻酚及其衍生物合成的合成途径，包括基于手性池的和不对称的化学及生物催化方法。
