Institute of Chemistry, University of Graz, Heinrichstraße 28, A-8010 Graz, Austria.
Center for Continuous Flow Synthesis and Processing (CCFLOW), Research Center Pharmaceutical Engineering GmbH (RCPE), Inffeldgasse 13, 8010 Graz, Austria.
J Org Chem. 2023 May 5;88(9):6227-6231. doi: 10.1021/acs.joc.3c00300. Epub 2023 Apr 4.
A challenging step in the preparation of tetrahydrocannabinol analogs is an acid-catalyzed intramolecular cyclization of the cannabidiol precursor. This step typically affords a mixture of products, which requires extensive purification to obtain any pure products. We report the development of two continuous-flow protocols for the preparation of (-)--Δ-tetrahydrocannabinol and (-)--Δ-tetrahydrocannabinol.
在四氢大麻酚类似物的制备中，具有挑战性的一步是大麻二酚前体的酸催化分子内环化。这一步通常会得到产物的混合物，需要进行大量的纯化才能得到任何纯的产物。我们报告了两种(-)--Δ-四氢大麻酚和(-)--Δ-四氢大麻酚制备的连续流方案的开发。
