Department of Information Engineering, I-Shou University, Kaohsiung, Taiwan, ROC.
Department of Computer and Communication, National Pingtung University, Pingtung, Taiwan, ROC.
Kaohsiung J Med Sci. 2020 Jul;36(7):543-551. doi: 10.1002/kjm2.12213. Epub 2020 Apr 7.
The functional abnormality of brain areas accounting for the migraine remains to be elucidated. Most related studies have used functional magnetic resonance imaging to investigate brain areas involved in migraine. However, the results are heterogeneous. In this study, we used a convenient tool to explore the brain regions involved in migraine. In this study, 40 children with migraine and 40 sex- and age-matched health controls were enrolled, and electroencephalogram was used to explore the functional abnormal areas of migraine through electroencephalogram bands and low-resolution electromagnetic tomography analysis. The results revealed that spectrum edge frequency 50 in all electroencephalogram channels in patients with migraine were lower than those in controls. Significant differences were discovered over frontal areas. In addition, significantly higher current density over the frontopolar prefrontal cortex and orbitofrontal cortex and higher connectivity over the left prefrontal cortex were observed in patients with migraine. We suggest that functional disturbance of the prefrontal cortex may play a potential role in children with migraine, and that low-resolution electromagnetic tomography is a reliable and convenient tool for studying the functional disturbance of migraine.
大脑区域导致偏头痛的功能异常仍待阐明。大多数相关研究都使用功能磁共振成像来研究偏头痛相关的大脑区域。然而，结果存在异质性。在本研究中，我们使用了一种便捷的工具来探索偏头痛涉及的大脑区域。本研究纳入了 40 例偏头痛患儿和 40 例性别和年龄匹配的健康对照者，通过脑电图频段和低分辨率电磁断层扫描分析，使用脑电图来探索偏头痛的功能异常区域。结果显示，偏头痛患儿所有脑电图通道的频谱边缘频率 50 均低于对照组。在前额区域发现了显著差异。此外，偏头痛患儿的额极前额叶皮质和眶额皮质的电流密度明显升高，左前额叶皮质的连通性也升高。我们认为，前额叶皮质的功能障碍可能在偏头痛患儿中发挥潜在作用，低分辨率电磁断层扫描是研究偏头痛功能障碍的可靠且便捷的工具。
