Fox Chase Cancer Center.
The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute.
J Natl Compr Canc Netw. 2020 Apr;18(4):380-391. doi: 10.6004/jnccn.2020.0017.
The NCCN Guidelines for Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic provide recommendations for genetic testing and counseling for hereditary cancer syndromes, and risk management recommendations for patients who are diagnosed with syndromes associated with an increased risk of these cancers. The NCCN panel meets at least annually to review comments, examine relevant new data, and reevaluate and update recommendations. These NCCN Guidelines Insights summarize the panel's discussion and most recent recommendations regarding criteria for high-penetrance genes associated with breast and ovarian cancer beyond BRCA1/2, pancreas screening and genes associated with pancreatic cancer, genetic testing for the purpose of systemic therapy decision-making, and testing for people with Ashkenazi Jewish ancestry.
NCCN 遗传/家族性高风险评估指南：乳腺、卵巢和胰腺为遗传性癌症综合征提供了基因检测和咨询建议，以及与这些癌症风险增加相关的综合征诊断患者的风险管理建议。NCCN 小组至少每年开会一次，以审查意见、检查相关新数据，并重新评估和更新建议。这些 NCCN 指南洞察总结了小组关于与 BRCA1/2 以外的乳腺癌和卵巢癌、胰腺筛查和与胰腺癌相关的基因相关的高外显率基因、用于系统治疗决策的基因检测以及具有阿什肯纳兹犹太血统的人的检测标准的讨论和最新建议。
