Dianat-Moghadam Hassan, Azizi Mehdi, Eslami-S Zahra, Cortés-Hernández Luis Enrique, Heidarifard Maryam, Nouri Mohammad, Alix-Panabières Catherine
Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz 51368, Iran.
Student Research Committee, Tabriz University of Medical Sciences, Tabriz 51368, Iran.
Cancers (Basel). 2020 Apr 3;12(4):867. doi: 10.3390/cancers12040867.
Metastases and cancer recurrence are the main causes of cancer death. Circulating Tumor Cells (CTCs) and disseminated tumor cells are the drivers of cancer cell dissemination. The assessment of CTCs' clinical role in early metastasis prediction, diagnosis, and treatment requires more information about their biology, their roles in cancer dormancy, and immune evasion as well as in therapy resistance. Indeed, CTC functional and biochemical phenotypes have been only partially characterized using murine metastasis models and liquid biopsy in human patients. CTC detection, characterization, and enumeration represent a promising tool for tailoring the management of each patient with cancer. The comprehensive understanding of CTCs will provide more opportunities to determine their clinical utility. This review provides much-needed insights into this dynamic field of translational cancer research.
转移和癌症复发是癌症死亡的主要原因。循环肿瘤细胞（CTCs）和播散肿瘤细胞是癌细胞播散的驱动因素。评估CTCs在早期转移预测、诊断和治疗中的临床作用，需要更多关于其生物学特性、在癌症休眠和免疫逃逸以及治疗抗性中的作用的信息。事实上，使用小鼠转移模型和人类患者的液体活检仅部分表征了CTCs的功能和生化表型。CTCs的检测、表征和计数是为每位癌症患者量身定制治疗方案的一个有前景的工具。对CTCs的全面了解将为确定其临床效用提供更多机会。本综述为这一动态的转化癌症研究领域提供了急需的见解。
