一种黑色素瘤脑转移循环肿瘤细胞特征及循环肿瘤细胞：B细胞簇与继发性肝转移相关：黑色素瘤脑-肝转移轴
A Melanoma Brain Metastasis CTC Signature and CTC:B-cell Clusters Associate with Secondary Liver Metastasis: A Melanoma Brain-Liver Metastasis Axis.
作者信息
Bowley Tetiana Y, Ortiz Mireya C, Lagutina Irina V, Steinkamp Mara P, Fahy Bridget N, Tawfik Bernard, Harari-Turquie Moises, Marchetti Dario
机构信息
Division of Molecular Medicine, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico.
Animal Models Shared Resource, The University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico.
出版信息
Cancer Res Commun. 2025 Feb 1;5(2):295-308. doi: 10.1158/2767-9764.CRC-24-0498.
This study provides important insights into the relevance of prometastatic CTC:B-cell clusters in melanoma progression, extends the importance of the CTC RPL/RPS gene signature beyond primary metastasis/melanoma brain metastasis driving targeted organ specificity for liver metastasis ("metastasis of metastasis"), and identifies new targets for clinical melanoma metastasis therapies.
本研究为促转移循环肿瘤细胞（CTC）：B细胞簇在黑色素瘤进展中的相关性提供了重要见解，将CTC核糖体蛋白大亚基/核糖体蛋白小亚基（RPL/RPS）基因特征的重要性扩展到原发性转移/黑色素瘤脑转移之外，其驱动肝转移的靶向器官特异性（“转移的转移”），并确定了临床黑色素瘤转移治疗的新靶点。
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