Group of Investigation in Interactions Gene-Environment and Health (GIIGAS)/Institute of Biomedicine (IBIOMED), Universidad de León, 24071 León, Spain.
Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet del Llobregat, 08908 Barcelona, Spain.
Nutrients. 2020 Apr 3;12(4):994. doi: 10.3390/nu12040994.
There is limited evidence of phenolic compounds acting as protective agents on several cancer types, including breast cancer (BC). Nevertheless, some polyphenol classes have not been investigated and there is a lack of studies assessing the effect on menopausal status and hormone receptor status as influenced by these compounds. The objective of this study is to evaluate the association between the intake of all polyphenol classes in relation to the BC risk by menopausal and hormone receptor status. We used data from a population-based multi-case-control study (MCC-Spain) including 1472 BC cases and 1577 controls from 12 different regions of Spain. The odds ratios (ORs) with 95% CI were calculated using logistic regression of mixed effects by quartiles and log2 of polyphenol intakes (adjusted for the residual method) of overall BC, menopausal and receptor status. No associations were found between total intake of polyphenols and BC risk. However, inverse associations were found between stilbenes and all BC risk (OR: 0.70, 95%CI: 0.56-0.89, = 0.001), the consumption of hydroxybenzaldehydes (OR: 0.75, 95%CI: 0.59-0.93, = 0.012) and hydroxycoumarins (OR: 0.73, 95%CI: 0.57-0.93; = 0.005) were also inversely associated. The intake of stilbenes, hydroxybenzaldehydes and hydroxycoumarins can contribute to BC reduction risk on all menopausal and receptor statuses.
只有有限的证据表明酚类化合物对几种癌症类型（包括乳腺癌）具有保护作用。然而，一些多酚类尚未被研究，并且缺乏评估这些化合物对绝经状态和激素受体状态影响的研究。本研究的目的是评估所有多酚类与绝经和激素受体状态相关的乳腺癌风险之间的关系。我们使用了来自基于人群的多病例对照研究（MCC-Spain）的数据，该研究包括来自西班牙 12 个不同地区的 1472 例乳腺癌病例和 1577 例对照。使用基于四分位数和多酚摄入量的对数 2（通过残差法调整）的混合效应逻辑回归，计算总体乳腺癌、绝经和受体状态的比值比（OR）及其 95%置信区间。多酚总摄入量与乳腺癌风险之间没有关联。然而，我们发现，与所有乳腺癌风险呈负相关的有：二苯乙烯（OR：0.70，95%CI：0.56-0.89， = 0.001）、羟基苯甲醛（OR：0.75，95%CI：0.59-0.93， = 0.012）和羟基香豆素（OR：0.73，95%CI：0.57-0.93； = 0.005）。二苯乙烯、羟基苯甲醛和羟基香豆素的摄入可能有助于降低所有绝经和受体状态下的乳腺癌风险。
