Torrado Juan José, Serrano Dolores R, Capilla Javier
Departament of Pharmaceutics and Food Technology, School of Pharmacy, Complutense University of Madrid, 28040 Madrid, Spain.
Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili and Institut d'Investigació Sanitària Pere Virgili (IISPV), 43201 Reus, Spain.
Pharmaceutics. 2020 Apr 4;12(4):324. doi: 10.3390/pharmaceutics12040324.
Fungal and parasitic diseases affect more than a billion people across the globe, one-sixth of the world's population, mostly located in developing countries. The lack of effective and safer treatments combined with a deficient diagnosis lead to serious chronic illness or even death. There is a mismatch between the rate of drug resistance and the development of new medicines. Formulation of antifungal and antiparasitic drugs adapted to different administration routes is challenging, bearing in mind their poor water solubility, which limits their bioavailability and efficacy. Hence, there is an unmet clinical need to develop vaccines and novel formulations and drug delivery strategies that can improve the bioavailability and therapeutic effect by enhancing their dissolution, increasing their chemical potency, stabilising the drug and targeting high concentration of drug to the infection sites. This Editorial regards the ten research contributions presented in the Special Issue "Antifungal and Antiparasitic Drug Delivery".
真菌和寄生虫疾病影响着全球超过10亿人，占世界人口的六分之一，这些人大多分布在发展中国家。缺乏有效且更安全的治疗方法，再加上诊断不足，会导致严重的慢性病甚至死亡。耐药率与新药研发之间存在不匹配的情况。考虑到抗真菌和抗寄生虫药物水溶性差，这限制了它们的生物利用度和疗效，因此开发适用于不同给药途径的制剂具有挑战性。因此，临床上迫切需要开发疫苗、新型制剂和药物递送策略，通过提高药物的溶解性、增强化学效力、稳定药物以及将高浓度药物靶向感染部位，来提高生物利用度和治疗效果。本社论关注了《抗真菌和抗寄生虫药物递送》特刊中发表的十篇研究论文。
