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阳离子聚对苯撑乙炔与树枝状聚乙烯的共轭作用可实现活细胞成像。

Conjugation of cationic poly(p-phenylene ethynylene) with dendritic polyethylene enables live-cell imaging.

作者信息

Zhang Ling, Yin Qihe, Huang Hongying, Wang Bingxing

机构信息

DSAPM Lab, PCFM Lab, and OFCM Institute, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China.

出版信息

J Mater Chem B. 2013 Feb 14;1(6):756-761. doi: 10.1039/c2tb00285j. Epub 2012 Dec 3.

DOI:10.1039/c2tb00285j
PMID:32260733
Abstract

A new system based on dendritic polyethylene-cationic poly(p-phenylene ethynylene) core-shell nanoparticles was developed for live-cell imaging. By using the combination of molecular-wire and "dendritic effects" strategies, this design provides the new system with higher photoluminescence quantum yields, lower cell viability and better cellular permeability compared with free cationic poly(p-phenylene ethynylene), allowing it to exhibit remarkable improvements in fluorescence imaging for live cells.

摘要

一种基于树枝状聚乙烯 - 阳离子聚对苯撑乙炔核壳纳米粒子的新系统被开发用于活细胞成像。通过结合分子线和“树枝状效应”策略,与游离的阳离子聚对苯撑乙炔相比,这种设计赋予新系统更高的光致发光量子产率、更低的细胞活力和更好的细胞渗透性,使其在活细胞荧光成像方面表现出显著改进。

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