Zhang Ling, Yin Qi-He, Li Jin-Ming, Huang Hong-Ying, Wu Qing, Mao Zong-Wan
DSAPM Lab, PCFM Lab, OFCM Institute, MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China.
J Mater Chem B. 2013 May 7;1(17):2245-2251. doi: 10.1039/c3tb00480e. Epub 2013 Mar 12.
A novel system based on a dendritic polyethylene-cationic poly(p-phenylene ethynylene) polyvalent nanocarrier was developed for siRNA delivery. By using the combination of a molecular wire and a "dendritic effects" strategy, this design provides the nanocarrier system with low cytotoxicity, cellular imaging and high siRNA delivery efficiency, allowing it to exhibit remarkable gene knockdown abilities as well as real-time monitoring of the siRNA delivery process.
开发了一种基于树枝状聚乙烯-阳离子聚对苯撑乙炔多价纳米载体的新型系统用于小干扰RNA（siRNA）递送。通过分子线与“树枝状效应”策略的结合，该设计赋予纳米载体系统低细胞毒性、细胞成像能力和高siRNA递送效率，使其能够展现出显著的基因敲低能力以及对siRNA递送过程的实时监测。
