Karavasili Christina, Amanatiadou Elsa P, Sygellou Lambrini, Giasafaki Dimitra K, Steriotis Theodore A, Charalambopoulou Georgia C, Vizirianakis Ioannis S, Fatouros Dimitrios G
Laboratory of Pharmaceutical Technology, Department of Pharmaceutical Sciences, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece.
J Mater Chem B. 2013 Jul 7;1(25):3167-3174. doi: 10.1039/c3tb20304b. Epub 2013 May 23.
Ordered mesoporous carbons that encapsulate the poorly soluble compounds ibuprofen and indomethacin were systematically studied by means of X-ray diffraction (XRD), differential scanning calorimetry (DSC) and X-ray photon electron spectroscopy (XPS). The results showed marked differences in the release profiles of the two drug molecules in simulated gastric fluids. In vitro toxicity profiles appear to be compatible with potential therapeutic applications bringing them to the forefront as carriers of poorly water soluble drugs.
通过X射线衍射（XRD）、差示扫描量热法（DSC）和X射线光电子能谱（XPS）对包封难溶性化合物布洛芬和吲哚美辛的有序介孔碳进行了系统研究。结果表明，两种药物分子在模拟胃液中的释放曲线存在显著差异。体外毒性曲线似乎与潜在的治疗应用相兼容，这使它们成为难溶性药物载体的前沿研究对象。
