• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

用于双癌症药物递送的形成多功能超分子水凝胶的前药。

Prodrugs forming multifunctional supramolecular hydrogels for dual cancer drug delivery.

作者信息

Ha Wei, Yu Jing, Song Xin-Yue, Zhang Zhi-Jun, Liu Ying-Qian, Shi Yan-Ping

机构信息

Key Laboratory of Chemistry of Northwestern Plant Resources of CAS, Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, P. R. China.

出版信息

J Mater Chem B. 2013 Nov 7;1(41):5532-5538. doi: 10.1039/c3tb20956c. Epub 2013 Sep 18.

DOI:10.1039/c3tb20956c
PMID:32261176
Abstract

Here we report a multifunctional supramolecular hydrogel based on host-guest inclusion for loading two different anticancer drugs with different controlled release profiles. The resulting hydrogels are characterized by possessing dual phase drug release behavior and producing a dose and cell type dependent synergetic cytotoxicity to cancer cells, which can be used for cancer combination therapy.

摘要

在此，我们报道了一种基于主客体包合作用的多功能超分子水凝胶，用于负载两种具有不同控释曲线的抗癌药物。所得水凝胶的特征在于具有双相药物释放行为，并对癌细胞产生剂量和细胞类型依赖性的协同细胞毒性，可用于癌症联合治疗。

相似文献

1
Prodrugs forming multifunctional supramolecular hydrogels for dual cancer drug delivery.用于双癌症药物递送的形成多功能超分子水凝胶的前药。
J Mater Chem B. 2013 Nov 7;1(41):5532-5538. doi: 10.1039/c3tb20956c. Epub 2013 Sep 18.
2
Tunable temperature-responsive supramolecular hydrogels formed by prodrugs as a codelivery system.由前药作为共递送系统形成的可调温响应超分子水凝胶。
ACS Appl Mater Interfaces. 2014 Jul 9;6(13):10623-30. doi: 10.1021/am5022864. Epub 2014 Jun 23.
3
Supramolecular hybrid hydrogel based on host-guest interaction and its application in drug delivery.基于主客体相互作用的超分子杂化水凝胶及其在药物传递中的应用。
ACS Appl Mater Interfaces. 2014 Nov 26;6(22):19544-51. doi: 10.1021/am505649q. Epub 2014 Nov 14.
4
Self-assembled supramolecular thermoreversible β-cyclodextrin/ethylene glycol injectable hydrogels with difunctional Pluronic127 as controlled delivery depot of curcumin. Development, characterization and in vitro evaluation.基于双官能化普朗尼克 127 的自组装超分子热可逆β-环糊精/乙二醇注射水凝胶作为姜黄素的控释储库。制备、表征和体外评价。
J Biomater Sci Polym Ed. 2018 Jan;29(1):1-34. doi: 10.1080/09205063.2017.1396707. Epub 2017 Oct 29.
5
Cyclodextrin-based host-guest supramolecular nanoparticles for delivery: from design to applications.基于环糊精的主体-客体超分子纳米粒子用于递药：从设计到应用。
Acc Chem Res. 2014 Jul 15;47(7):2017-25. doi: 10.1021/ar500055s. Epub 2014 May 29.
6
Supramolecular hydrogels co-loaded with camptothecin and doxorubicin for sustainedly synergistic tumor therapy.负载喜树碱和阿霉素的超分子水凝胶用于持续协同肿瘤治疗
J Mater Chem B. 2015 Mar 14;3(10):2127-2136. doi: 10.1039/c4tb01971g. Epub 2015 Feb 6.
7
Fabrication of a Micellar Supramolecular Hydrogel for Ocular Drug Delivery.用于眼部药物递送的胶束超分子水凝胶的制备
Biomacromolecules. 2016 Mar 14;17(3):798-807. doi: 10.1021/acs.biomac.5b01526. Epub 2016 Feb 12.
8
An injectable, dual pH and oxidation-responsive supramolecular hydrogel for controlled dual drug delivery.一种用于可控双药递送的可注射、双pH和氧化响应性超分子水凝胶。
Colloids Surf B Biointerfaces. 2016 May 1;141:44-52. doi: 10.1016/j.colsurfb.2016.01.034. Epub 2016 Jan 22.
9
Prodrugs forming high drug loading multifunctional nanocapsules for intracellular cancer drug delivery.前药形成高载药量多功能纳米胶囊用于细胞内癌症药物递送。
J Am Chem Soc. 2010 Mar 31;132(12):4259-65. doi: 10.1021/ja909475m.
10
Multifunctional smart hydrogels: potential in tissue engineering and cancer therapy.多功能智能水凝胶：在组织工程和癌症治疗中的潜力。
J Mater Chem B. 2018 Aug 7;6(29):4714-4730. doi: 10.1039/c8tb01078a. Epub 2018 Jul 4.

引用本文的文献

1
Hydrogel local drug delivery systems for postsurgical management of tumors: and perspectives.用于肿瘤术后管理的水凝胶局部给药系统：及展望。
Mater Today Bio. 2024 Oct 24;29:101308. doi: 10.1016/j.mtbio.2024.101308. eCollection 2024 Dec.
2
Co-Delivery of 8-Hydroxyquinoline Glycoconjugates and Doxorubicin by Supramolecular Hydrogel Based on α-Cyclodextrin and pH-Responsive Micelles for Enhanced Tumor Treatment.基于α-环糊精和pH响应性胶束的超分子水凝胶共递送8-羟基喹啉糖缀合物和阿霉素用于增强肿瘤治疗
Pharmaceutics. 2022 Nov 17;14(11):2490. doi: 10.3390/pharmaceutics14112490.
3
Self-assembled pH-responsive supramolecular hydrogel for hydrophobic drug delivery.
用于疏水性药物递送的自组装pH响应性超分子水凝胶
RSC Adv. 2018 Sep 10;8(55):31581-31587. doi: 10.1039/c8ra06064a. eCollection 2018 Sep 5.
4
Sulfonamide as amide isostere for fine-tuning the gelation properties of physical gels.作为酰胺电子等排体的磺胺用于微调物理凝胶的凝胶化性质。
RSC Adv. 2020 Mar 20;10(19):11481-11492. doi: 10.1039/d0ra00943a. eCollection 2020 Mar 16.
5
Pluronic F127-Modified Electrospun Fibrous Meshes for Synergistic Combination Chemotherapy of Colon Cancer.用于结肠癌协同联合化疗的普朗尼克F127修饰电纺纤维网
Front Bioeng Biotechnol. 2021 Feb 16;8:618516. doi: 10.3389/fbioe.2020.618516. eCollection 2020.
6
Engineering of Peglayted Camptothecin Into Nanomicelles and Supramolecular Hydrogels for Pesticide Combination Control.聚乙二醇化喜树碱制备纳米胶束和超分子水凝胶用于农药联合控释
Front Chem. 2020 Jan 15;7:922. doi: 10.3389/fchem.2019.00922. eCollection 2019.
7
Weak Bond-Based Injectable and Stimuli Responsive Hydrogels for Biomedical Applications.用于生物医学应用的基于弱键的可注射及刺激响应水凝胶
J Mater Chem B. 2017 Feb 7;5(5):887-906. doi: 10.1039/C6TB03052A. Epub 2016 Dec 16.
8
Building Nanostructures with Drugs.用药物构建纳米结构
Nano Today. 2016 Feb;11(1):13-30. doi: 10.1016/j.nantod.2015.11.003.
9
Co-delivery of camptothecin and curcumin by cationic polymeric nanoparticles for synergistic colon cancer combination chemotherapy.阳离子聚合物纳米粒共递送喜树碱和姜黄素用于协同结肠癌联合化疗
J Mater Chem B. 2015 Oct 21;3(39):7724-7733. doi: 10.1039/c5tb01245g. Epub 2015 Sep 1.
10
Hyaluronic acid-functionalized polymeric nanoparticles for colon cancer-targeted combination chemotherapy.用于结肠癌靶向联合化疗的透明质酸功能化聚合物纳米颗粒
Nanoscale. 2015 Nov 14;7(42):17745-55. doi: 10.1039/c5nr04831a. Epub 2015 Oct 12.