Li Xian, Su Xiulan
Clinical Medical Research Center of the Affiliated Hospital, Inner Mongolia Medical University, 1 Tong Dao Street, Hohhot 010050, Inner Mongolia Autonomous Region, P. R. China.
J Mater Chem B. 2018 Aug 7;6(29):4714-4730. doi: 10.1039/c8tb01078a. Epub 2018 Jul 4.
In recent years, clinical applications have been proposed for various hydrogel products. Hydrogels can be derived from animal tissues, plant extracts and/or adipose tissue extracellular matrices; each type of hydrogel presents significantly different functional properties and may be used for many different applications, including medical therapies, environmental pollution treatments, and industrial materials. Due to complicated preparation techniques and the complexities associated with the selection of suitable materials, the applications of many host-guest supramolecular polymeric hydrogels are limited. Thus, improvements in the design and construction of smart materials are highly desirable in order to increase the lifetimes of functional materials. Here, we summarize different functional hydrogels and their varied preparation methods and source materials. The multifunctional properties of hydrogels, particularly their unique ability to adapt to certain environmental stimuli, are chiefly based on the incorporation of smart materials. Smart materials may be temperature sensitive, pH sensitive, pH/temperature dual sensitive, photoresponsive or salt responsive and may be used for hydrogel wound repair, hydrogel bone repair, hydrogel drug delivery, cancer therapy, and so on. This review focuses on the recent development of smart hydrogels for tissue engineering applications and describes some of the latest advances in using smart materials to create hydrogels for cancer therapy.
近年来，各种水凝胶产品已被提出用于临床应用。水凝胶可以来源于动物组织、植物提取物和/或脂肪组织细胞外基质；每种类型的水凝胶都具有显著不同的功能特性，可用于许多不同的应用，包括医学治疗、环境污染处理和工业材料。由于制备技术复杂以及选择合适材料相关的复杂性，许多主客体超分子聚合物水凝胶的应用受到限制。因此，为了延长功能材料的使用寿命，非常需要改进智能材料的设计和构建。在此，我们总结了不同的功能水凝胶及其多样的制备方法和原料。水凝胶的多功能特性，特别是其适应特定环境刺激的独特能力，主要基于智能材料的加入。智能材料可以是温度敏感、pH敏感、pH/温度双敏感、光响应或盐响应的，可用于水凝胶伤口修复、水凝胶骨修复、水凝胶药物递送、癌症治疗等。本综述重点关注用于组织工程应用的智能水凝胶的最新进展，并描述了使用智能材料制备用于癌症治疗的水凝胶的一些最新进展。
