Mellal Denia, Zumbuehl Andreas
Department of Chemistry, University of Fribourg, Chemin du Musée 9, 1700 Fribourg, Switzerland.
J Mater Chem B. 2014 Jan 21;2(3):247-252. doi: 10.1039/c3tb21086c. Epub 2013 Nov 28.
This highlight describes recent trends in fundamental phospholipid research towards possible future drug delivery technology. In particular it focuses on synthetic phospholipids and their vesicular constructs and describes selected "smart" ways to release cargo from liposomes. Various chemical and physical release triggers are discussed such as temperature changes, application of ultrasound, enzyme degradation, changes in pH, redox reactions, photochemical reactions, as well as the effects of shear stress on vesicles.
本综述重点介绍了基础磷脂研究在未来药物递送技术方面的最新趋势。特别关注合成磷脂及其囊泡结构，并描述了从脂质体中释放货物的特定“智能”方式。讨论了各种化学和物理释放触发因素，如温度变化、超声应用、酶降解、pH值变化、氧化还原反应、光化学反应以及剪切应力对囊泡的影响。
