Chimie ParisTech, PSL University Paris, CNRS, Institut de Recherche de Chimie Paris, UMR8247, 11 rue Pierre et Marie Curie, 75005 Paris, France.
Nanoscale. 2018 Apr 19;10(15):6781-6800. doi: 10.1039/c8nr00923f.
This paper reviews liposomes with crystalline phase and polymersomes exhibiting crystalline and thermotropic liquid crystalline phases in the membrane. Intriguing morphologies of vesicles are described, including spherical, ellipsoidal and faceted vesicles, produced by a large variety of amphiphilic molecules and polymers with nematic phase, smectic phase or crystalline phase. It is highlighted how the phase transitions and the phase grain boundaries could be used ingeniously to destabilize the vesicular structure and to achieve cargo-release under the action of external stimulation. These liposomes and polymersomes are responsive to physical stimuli, such as temperature variation, shear stress, light illumination, and magnetic and electric fields. These stimuli-responsive properties make them promising candidates as new smart drug delivery systems.
本文综述了具有晶相的脂质体和聚合物囊泡，它们在膜中表现出晶相和热致液晶相。描述了各种具有向列相、层状相或晶相的两亲分子和聚合物所产生的具有迷人形态的囊泡，包括球形、椭圆形和有面的囊泡。重点介绍了如何巧妙地利用相转变和相晶界来破坏囊泡结构，并在外力刺激下实现货物释放。这些脂质体和聚合物囊泡对物理刺激（如温度变化、剪切应力、光照以及磁场和电场）有响应。这些刺激响应特性使它们成为有前途的新型智能药物输送系统的候选者。
