Lee Junseok, Jeong Cherlhyun, Kim Won Jong
Center for Self-assembly and Complexity, Institute for Basic Science, Department of Chemistry, Polymer Research Institute, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Republic of Korea.
J Mater Chem B. 2014 Dec 21;2(47):8338-8345. doi: 10.1039/c4tb01631a. Epub 2014 Oct 24.
Near-IR (NIR)-responsive drug delivery systems have received enormous attention because of their good biocompatibility and the high biological penetration of NIR. This work describes the facile fabrication and anticancer effect of a NIR-responsive drug delivery system based on the nano-assembly of mesoporous silica-coated gold nanorods (AuNR@mSiO) and a phase change material (PCM). The core gold nanorods in AuNR@mSiO provided excellent NIR sensitivity, and the mesoporous silica shell provided an increased reservoir of loaded drug. The PCM was applied as both a thermosensitive gatekeeper and a medium for a hydrophobic anticancer drug. The photothermal effect of the AuNRs under NIR irradiation facilitated a rapid release of the drug through the temperature-sensitive phase transition of PCM at just above body temperature. An enhanced anticancer effect was observed against various cell lines, and intracellular release of the drug was easily monitored by live cell imaging. Our system does not require any complicated synthetic methods for fabrication, and PCM is easily capable of solubilizing various hydrophobic drugs. Therefore, this system has significant potential for broad application in the biomedical field as a delivery system for hydrophobic drugs with NIR-responsive behavior.
近红外（NIR）响应型药物递送系统因其良好的生物相容性和近红外光的高生物穿透性而受到广泛关注。本文描述了一种基于介孔二氧化硅包覆金纳米棒（AuNR@mSiO）与相变材料（PCM）的纳米组装体的近红外响应型药物递送系统的简易制备及其抗癌效果。AuNR@mSiO中的核心金纳米棒具有出色的近红外敏感性，介孔二氧化硅壳层增加了药物负载量。PCM既作为热敏守门人，又作为疏水性抗癌药物的载体。近红外辐射下金纳米棒的光热效应通过PCM在略高于体温时的温度敏感相变促进了药物的快速释放。在多种细胞系中均观察到增强的抗癌效果，并且通过活细胞成像可轻松监测药物在细胞内的释放情况。我们的系统制备不需要任何复杂的合成方法，并且PCM能够轻松溶解各种疏水性药物。因此，作为具有近红外响应行为的疏水性药物的递送系统，该系统在生物医学领域具有广阔的应用潜力。
