通过单线态氧敏感连接体包被聚合物的阿霉素/二氢卟吩e6负载纳米颗粒用于光动力辅助化疗
Doxorubicin/Ce6-Loaded Nanoparticle Coated with Polymer via Singlet Oxygen-Sensitive Linker for Photodynamically Assisted Chemotherapy.
作者信息
Lee Junseok, Lee Yeong Mi, Kim Jinhwan, Kim Won Jong
机构信息
Center for Self-assembly and Complexity, Institute of Basic Science (IBS), Pohang, 37673, Korea.
Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang, 37673, Korea.
出版信息
Nanotheranostics. 2017 May 8;1(2):196-207. doi: 10.7150/ntno.18576. eCollection 2017.
Abstract
It is widely known that the therapeutic effect of nanoparticle-based chemotherapeutics could be greatly enhanced by the introduction of the photodynamic effect. Herein we report a chlorin e6-incorporated mesoporous silica nanoparticles (MSNs) covered with a polyethylene glycol shell conjugated a singlet oxygen-sensitive labile bis(alkylthio)alkene linker (CeAP-L-PEG). In this study, single irradiation with biocompatible red light induced both intracellular doxorubicin release and photochemical internalization, and consequently enhanced anti-cancer effect was observed and . This study suggests the potential of our precisely designed nanoparticle system for photodynamically assisted chemotherapy.
摘要
众所周知，引入光动力效应可大大增强基于纳米颗粒的化疗药物的治疗效果。在此，我们报道了一种包裹有聚乙二醇壳并缀合了单线态氧敏感的不稳定双（烷硫基）烯烃连接体（CeAP-L-PEG）的二氢卟吩e6掺入的介孔二氧化硅纳米颗粒（MSN）。在本研究中，用生物相容性红光单次照射可诱导细胞内阿霉素释放和光化学内化，因此观察到抗癌效果增强。本研究表明了我们精确设计的纳米颗粒系统用于光动力辅助化疗的潜力。
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