Skilling K J, Ndungu A, Kellam B, Ashford M, Bradshaw T D, Marlow M
School of Pharmacy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
J Mater Chem B. 2014 Dec 21;2(47):8412-8417. doi: 10.1039/c4tb01375a. Epub 2014 Oct 29.
In this study we report the synthesis of new cytidine derived gelators possessing acyl chains of different lengths. These low molecular weight gelators were shown to form self-supporting gels at 0.5% (w/v) in binary systems of aqueous miscible polar organic solvent and water. The representative gels were studied using rheology and their fibrillar structure confirmed by TEM imaging and FTIR. We further demonstrated the use of these gels as potential drug delivery platforms by monitoring release characteristics of both high and low molecular weight fluorescently labelled tracers.
在本研究中，我们报道了具有不同长度酰基链的新型胞苷衍生凝胶剂的合成。这些低分子量凝胶剂在与水互溶的极性有机溶剂和水的二元体系中，浓度为0.5%（w/v）时能形成自支撑凝胶。使用流变学对代表性凝胶进行了研究，并通过透射电子显微镜成像和傅里叶变换红外光谱证实了它们的纤维状结构。我们通过监测高分子量和低分子量荧光标记示踪剂的释放特性，进一步证明了这些凝胶作为潜在药物递送平台的用途。
