Zhang Xu, Zhao Yuanyuan, Xu Yi, Pan Yuanming, Chen Fei, Kumar Anil, Zou Guozhang, Liang Xing-Jie
National Center for Nanoscience and Technology, No. 11 Zhongguancun Beiyitiao, Beijing, 100190, China.
J Mater Chem B. 2014 Sep 21;2(35):5882-5890. doi: 10.1039/c4tb00626g. Epub 2014 Aug 1.
In this study, an orally administered macrophage-targeting peptide delivery system was constructed through in situ self-assembly of Q11 peptide inside hollow glucan particles (GPs), which are approved by the FDA. The glucan shell efficiently protected the encapsulated peptide from enzymatic degradation in the gastrointestinal tract. β-1,3-(d)-Glucan is recognized by the membrane receptor dectin-1, which is highly expressed by intestinal antigen-presenting cells, including macrophages. GPs are thus efficiently phagocytized by intestinal macrophages. This study is applicable to the pharmaceutical industry for the development of orally delivered macrophage-targeting systems for effective and personalized remedies like immunotherapeutic vaccines.
在本研究中，通过Q11肽在经美国食品药品监督管理局（FDA）批准的中空葡聚糖颗粒（GPs）内原位自组装，构建了一种口服巨噬细胞靶向肽递送系统。葡聚糖外壳有效地保护了包封的肽在胃肠道中免受酶降解。β-1,3-(d)-葡聚糖可被膜受体dectin-1识别，该受体在包括巨噬细胞在内的肠道抗原呈递细胞中高表达。因此，GPs能被肠道巨噬细胞有效吞噬。本研究适用于制药行业，用于开发口服巨噬细胞靶向系统，以实现免疫治疗疫苗等有效且个性化疗法的递送。
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