靶向递送葡聚糖颗粒包裹的镓纳米颗粒可抑制HIV在人巨噬细胞中的生长。
Targeted Delivery of Glucan Particle Encapsulated Gallium Nanoparticles Inhibits HIV Growth in Human Macrophages.
作者信息
Soto Ernesto R, O'Connell Olivia, Dikengil Fusun, Peters Paul J, Clapham Paul R, Ostroff Gary R
机构信息
Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA.
出版信息
J Drug Deliv. 2016;2016:8520629. doi: 10.1155/2016/8520629. Epub 2016 Nov 14.
Glucan particles (GPs) are hollow, porous 3-5 m microspheres derived from the cell walls of Baker's yeast ( The 1,3--glucan outer shell provides for receptor-mediated uptake by phagocytic cells expressing -glucan receptors. GPs have been used for macrophage-targeted delivery of a wide range of payloads (DNA, siRNA, protein, small molecules, and nanoparticles) encapsulated inside the hollow GPs or bound to the surface of chemically derivatized GPs. Gallium nanoparticles have been proposed as an inhibitory agent against HIV infection. Here, macrophage targeting of gallium using GPs provides for more efficient delivery of gallium and inhibition of HIV infection in macrophages compared to free gallium nanoparticles.
葡聚糖颗粒（GPs）是由面包酵母细胞壁衍生而来的中空、多孔的3-5微米微球。其1,3-β-葡聚糖外壳可被表达β-葡聚糖受体的吞噬细胞通过受体介导摄取。GPs已被用于巨噬细胞靶向递送多种包裹在中空GPs内部或与化学衍生化GPs表面结合的payloads（DNA、siRNA、蛋白质、小分子和纳米颗粒）。镓纳米颗粒已被提议作为一种抗HIV感染的抑制剂。在此，与游离镓纳米颗粒相比，利用GPs对镓进行巨噬细胞靶向可实现更高效的镓递送以及对巨噬细胞中HIV感染的抑制。
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