Karthik S, Prashanth Kumar B N, Gangopadhyay Moumita, Mandal Mahitosh, Singh N D Pradeep
Department of Chemistry, Indian Institute of Technology, Kharagpur, India.
J Mater Chem B. 2015 Feb 7;3(5):728-732. doi: 10.1039/c4tb01583e. Epub 2014 Dec 17.
We have developed a new targeted image-guided photoresponsive drug delivery system (DDS) based on a dual locking strategy. Excitation of the DDS by fluorescent light results in the first unlocking and activation of the drug, and allows real-time monitoring of the prodrug. Extended irradiation results in a second unlocking, giving drug release within cancer cells.
我们基于双重锁定策略开发了一种新型的靶向图像引导光响应药物递送系统（DDS）。通过荧光对该DDS进行激发会导致药物的首次解锁和激活，并能够对前药进行实时监测。延长照射会导致第二次解锁，从而使药物在癌细胞内释放。
