Schimmel D, Pospisil Z, Schimmel I, Schulze F, Vogt A
Arch Exp Veterinarmed. 1977;31(1):15-27.
Store pigs with spontaneous outbreaks and experimental endotoxin shock were kept under observation in the context of coagulation analysis. Heparin was applied to some of the animals to disrupt the plasmatic coagulation system. The thrombocyte count in animals with endotoxin infusion declined by some 50 to 65 percent of the original level. No statistically secured difference was found to exist between heparinised animals, on the one hand, and non-heparinised, on the other. The aggregation and adhesion of thrombocytes in all shock animals was more pronounced than that in the controls. The fibrinogen levels were lowered in both the animals with spontaneous outbreaks and the experimental animals. Thrombocyte alteration was not found to have been dependent on activation of the plasmatic coagulation system. In endotoxin shock cases activation of plasmatic coagulation proteins was found to be preceded by rise in thrombocyte aggregation.
对发生自发性疫情的猪以及实验性内毒素休克猪进行凝血分析观察。对部分动物使用肝素以破坏血浆凝血系统。内毒素注入动物的血小板计数下降至原水平的约50%至65%。一方面，使用肝素的动物与未使用肝素的动物之间未发现统计学上有可靠依据的差异。所有休克动物的血小板聚集和黏附比对照组更明显。自发性疫情动物和实验动物的纤维蛋白原水平均降低。未发现血小板改变依赖于血浆凝血系统的激活。在内毒素休克病例中，发现血浆凝血蛋白的激活先于血小板聚集增加。
