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Collagen-induced arthritis in the mouse.

作者信息

Wooley P H

出版信息

Methods Enzymol. 1988;162:361-73. doi: 10.1016/0076-6879(88)62091-x.

DOI:10.1016/0076-6879(88)62091-x
PMID:3226317
Abstract
摘要

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1
Collagen-induced arthritis in the mouse.
Methods Enzymol. 1988;162:361-73. doi: 10.1016/0076-6879(88)62091-x.
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Type II collagen-induced arthritis in rats.
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Cartilage damage and bone erosion are more prominent determinants of functional impairment in longstanding experimental arthritis than synovial inflammation.在长期实验性关节炎中,软骨损伤和骨质侵蚀比滑膜炎症更是功能障碍的突出决定因素。
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IL-1 alpha beta blockade prevents cartilage and bone destruction in murine type II collagen-induced arthritis, whereas TNF-alpha blockade only ameliorates joint inflammation.白细胞介素-1αβ阻断可预防小鼠Ⅱ型胶原诱导性关节炎中的软骨和骨质破坏,而肿瘤坏死因子-α阻断仅能改善关节炎症。
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[Effects of hydrocortisone on articular cartilage glycosaminoglycans in Freund's adjuvant and collagen-induced arthritis].
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Cell therapy using allogeneic bone marrow mesenchymal stem cells prevents tissue damage in collagen-induced arthritis.使用异基因骨髓间充质干细胞的细胞疗法可预防胶原诱导性关节炎中的组织损伤。
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Cysteine proteinase inhibitors decrease articular cartilage and bone destruction in chronic inflammatory arthritis.半胱氨酸蛋白酶抑制剂可减少慢性炎症性关节炎中关节软骨和骨质破坏。
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Cartilage destruction in collagen induced arthritis assessed with a new biochemical marker for collagen type II C-telopeptide fragments.采用一种针对II型胶原C-末端肽片段的新生化标志物评估胶原诱导性关节炎中的软骨破坏情况。
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Extra-articular cartilage affected in collagen-induced, but not pristane-induced, arthritis models.在胶原诱导而非 pristane 诱导的关节炎模型中,关节外软骨受到影响。
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Effect of NOS2 gene deficiency on the development of autoantibody mediated arthritis and subsequent articular cartilage degeneration.一氧化氮合酶2(NOS2)基因缺陷对自身抗体介导的关节炎发展及随后关节软骨退变的影响。
J Rheumatol. 2003 Feb;30(2):247-55.

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