Hashida Ryoichi, Shimozuru Yasunori, Chang Jessica, Agosto-Marlin Ibis, Waritani Takaki, Terato Kuniaki
Chondrex Inc., 16928 Woodinville-Redmond Rd NE STE B101, Woodinville, WA 98072, USA.
Autoimmune Dis. 2021 Mar 25;2021:7385106. doi: 10.1155/2021/7385106. eCollection 2021.
Much public research suggests that autoimmune diseases such as rheumatoid arthritis (RA) are induced by aberrant "self" immune responses attacking autologous tissues and organ components. However, recent studies have reported that autoimmune diseases may be triggered by dysbiotic composition changes of the intestinal bacteria and an imbalance between these bacteria and intestinal immune systems. However, there are a few solid concepts or methods to study the putative involvement and relationship of these inner environmental factors in RA pathogenesis. Fortunately, Collagen-Induced Arthritis (CIA) and Collagen Antibody-Induced Arthritis (CAIA) models have been widely used as animal models for studying the pathogenesis of RA. In addition to RA, these models can be extensively used as animal models for studying complicated hypotheses in many diseases. In this review, we introduce some basic information about the CIA and CAIA models as well as how to apply these models effectively to investigate relationships between the pathogenesis of autoimmune diseases, especially RA, and the dysbiosis of intestinal bacterial flora.
许多公共研究表明，类风湿性关节炎（RA）等自身免疫性疾病是由异常的“自身”免疫反应攻击自体组织和器官成分所致。然而，最近的研究报告称，自身免疫性疾病可能由肠道细菌的生态失调组成变化以及这些细菌与肠道免疫系统之间的失衡引发。然而，目前几乎没有坚实的概念或方法来研究这些内在环境因素在类风湿性关节炎发病机制中的假定参与情况及其关系。幸运的是，胶原诱导性关节炎（CIA）和胶原抗体诱导性关节炎（CAIA）模型已被广泛用作研究类风湿性关节炎发病机制的动物模型。除了类风湿性关节炎外，这些模型还可广泛用作研究许多疾病复杂假说的动物模型。在本综述中，我们介绍了一些关于CIA和CAIA模型的基本信息，以及如何有效应用这些模型来研究自身免疫性疾病，尤其是类风湿性关节炎的发病机制与肠道菌群失调之间的关系。
