带正电荷的武装纳米颗粒在脉络膜视网膜疾病的有效治疗中展现出其精准的递送性能。
Positively charged armed nanoparticles demonstrate their precise delivery performance for effective treatment of chorioretinal diseases.
作者信息
Wei Wei, Zhu Dan, Wang Zhenhua, Ni Dezhi, Yue Hua, Wang Shuang, Tao Yong, Ma Guanghui
机构信息
National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
出版信息
J Mater Chem B. 2016 Apr 21;4(15):2548-2552. doi: 10.1039/c5tb02568k. Epub 2016 Mar 30.
Recruiting positively charged armed nanoparticles into the ocular fundus was achieved by utilizing the natural intraocular electrical field. Their subsequent penetration into the fundus sub-layers was also tuned by optimizing the surface charge density. In addition to the sustained release behavior, such a precise delivery fulfilled various intraocular delivery requirements for different chorioretinal diseases.
通过利用眼内自然电场，将带正电荷的武装纳米颗粒招募到眼底得以实现。它们随后向眼底亚层的渗透也通过优化表面电荷密度进行了调节。除了缓释行为外，这种精确递送满足了针对不同脉络膜视网膜疾病的各种眼内递送要求。
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