Institute of Pharmacy, Free University of Berlin, Kelchstr. 31, 12169 Berlin, Germany.
Int J Pharm. 2012 Jul 1;430(1-2):247-52. doi: 10.1016/j.ijpharm.2012.03.040. Epub 2012 Apr 2.
The surface of all tissues, including the stratum corneum, carries a negative charge. Following that fact it is assumed that a positively charged topical formulation could lead to an enhanced penetration because of an increased interaction with the negative charge of the membrane. The intention of this study is to prove an enhanced penetration of a positively charged nanoemulsion compared to a negatively charged nanoemulsion, both containing prednicarbate. The release and penetration of these nanoemulsions, produced with the high pressure homogenization method, were investigated. Regarding these results reveals that the release of the negatively charged formulation is higher compared to the positively charged nanoemulsion, while the penetration of the positively charged nanoemulsion is enhanced compared to the negatively charged formulation. The results of the investigated positively charged nanoemulsion containing prednicarbate show that its topical use could be advantageous for the therapy of atopic dermatitis, especially regarding phytosphingosine, which was responsible for the positive charge.
所有组织的表面，包括角质层，都带有负电荷。基于这一事实，可以假设带正电荷的局部制剂可以通过增加与膜负电荷的相互作用而导致渗透增强。本研究的目的是证明与带负电荷的纳米乳剂相比，带正电荷的纳米乳剂（均含有丙酸氯倍他索）的渗透增强。用高压匀质法制备这些纳米乳剂，并对其释放和渗透进行了研究。结果表明，与带负电荷的纳米乳剂相比，带正电荷的纳米乳剂的释放更高，而带正电荷的纳米乳剂的渗透增强。含有丙酸氯倍他索的研究用带正电荷的纳米乳剂的结果表明，其局部应用可能有利于特应性皮炎的治疗，特别是对于负责正电荷的植物鞘氨醇。
