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由磁场或电场驱动的用于药物递送的自推进液态金属马达。

Self-propelled liquid metal motors steered by a magnetic or electrical field for drug delivery.

作者信息

Zhang Jie, Guo Rui, Liu Jing

机构信息

Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China.

出版信息

J Mater Chem B. 2016 Aug 28;4(32):5349-5357. doi: 10.1039/c6tb00996d. Epub 2016 Jul 19.

DOI:10.1039/c6tb00996d
PMID:32263458
Abstract

Self-propelled motors have inspired enormous potential in accomplishing various tasks when navigating in an aqueous environment due to their virtues of requiring no external energy source and autonomous locomotion. However, without reliable controllability, their potential value would be heavily reduced. Here, we demonstrate an innovative millimeter-scale self-propelled motor steered by an external magnetic or electric field, which successfully enables the motor to avoid out-of-control motion behavior encountered previously. A nickel cap is electroplated on a liquid metal droplet. The on-board fuel aluminum foil not only triggers the autonomous movement, but also enhances the adhesion between the nickel cap and the droplet. The current motor, composed of a nickel cap, aluminum and liquid metal, is capable of running with a velocity of 3 cm s for hours without the use of an external energy source. In addition, the integration of the nickel cap renders a magnetic field exploitable to easily alter the performance of the motor remotely. Furthermore, an external electrical field offers a feasible way to accelerate the motor directionally in a reliable manner. More importantly, as a conceptual experiment, when loaded with soft alginate-based biomaterial containing aluminium nanoparticles as drugs, such a motor is still able to be self-propelled, exhibiting steerable motion for drug delivery. The remarkable features of the liquid metal motor, such as softness, controllable self-propelled movement and drug-delivery application, represent a critical step toward functional intelligent soft robots or machines.

摘要

自推进式马达由于无需外部能源和自主运动的优点,在水性环境中导航时完成各种任务具有巨大潜力。然而,如果没有可靠的可控性,它们的潜在价值将大幅降低。在此,我们展示了一种由外部磁场或电场控制的创新型毫米级自推进式马达,它成功地使马达避免了先前遇到的失控运动行为。在液态金属微滴上电镀一个镍帽。内置的燃料铝箔不仅触发自主运动,还增强了镍帽与微滴之间的附着力。当前由镍帽、铝和液态金属组成的马达,在不使用外部能源的情况下,能够以3厘米/秒的速度运行数小时。此外,镍帽的集成使得磁场可被利用,从而轻松远程改变马达的性能。此外,外部电场提供了一种可行的方法,能够可靠地定向加速马达。更重要的是,作为一个概念验证实验,当装载含有铝纳米颗粒作为药物的基于藻酸盐的软质生物材料时,这种马达仍然能够自行推进,表现出用于药物递送的可控运动。液态金属马达的显著特性,如柔软性、可控的自主运动和药物递送应用,代表了迈向功能性智能软机器人或机器的关键一步。

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