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多孔硅纳米颗粒作为癌症诊疗新兴平台的潜力。

Potential of porous silicon nanoparticles as an emerging platform for cancer theranostics.

作者信息

Stojanovic V, Cunin F, Durand J O, Garcia M, Gary-Bobo M

机构信息

Institut des Biomolécules Max Mousseron, UMR5247CNRS-UM, 15 Avenue Charles Flahault, BP 14491, 34093 Montpellier Cedex 05, France.

出版信息

J Mater Chem B. 2016 Nov 28;4(44):7050-7059. doi: 10.1039/c6tb01829g. Epub 2016 Oct 3.

Abstract

Currently, nanoscience is a major part of biomedical research, due to material advances that aid the development of new tools and techniques to replace traditional methods. To this end, the potential of porous silicon nanoparticles (pSiNPs) has been examined, especially in areas of cancer treatment and diagnosis. The properties of pSiNPs such as their porous structure, high surface area and porous volume, biocompatibility and biodegradability offer real opportunities for focal therapies that can avoid the side effects caused by conventional methods. This review is focused on pSiNPs and their potential application in targeted anticancer drug delivery, and photodynamic and thermal therapies. In addition, the luminescence properties of pSiNPS are useful in bioimaging and diagnosis. Hence, the theranostic potential of pSiNPs is discussed herein.

摘要

目前,由于材料技术的进步有助于开发新的工具和技术以取代传统方法,纳米科学已成为生物医学研究的重要组成部分。为此,人们已对多孔硅纳米颗粒(pSiNPs)的潜力进行了研究,尤其是在癌症治疗和诊断领域。pSiNPs的特性,如多孔结构、高表面积和孔体积、生物相容性和生物降解性,为聚焦治疗提供了切实机会,可避免传统方法引起的副作用。本综述聚焦于pSiNPs及其在靶向抗癌药物递送、光动力和热疗法中的潜在应用。此外,pSiNPS的发光特性在生物成像和诊断中很有用。因此,本文将讨论pSiNPs的治疗诊断潜力。

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