Li Nan, Niu Dechao, Jia Xiaobo, He Jianping, Jiang Yu, Gu Jinlou, Li Zheng, Xu Shiai, Li Yongsheng
Lab of Low-Dimensional Materials Chemistry, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.
J Mater Chem B. 2017 Feb 28;5(8):1642-1649. doi: 10.1039/c6tb03020c. Epub 2017 Feb 8.
Gold-based nanocomposites have attracted intensive attention due to their unique optical properties and great potential in biomedical applications. Herein, we report a simple route for the synthesis of multiple gold nanorods encapsulated, hierarchically porous silica nanospheres (MGNRs@HPSNs) based on the cooperative self-assembly of amphiphilic block copolymer polystyrene-b-poly (acrylic acid) (PS-b-PAA), cetyl trimethyl ammonium bromide (CTAB), gold nanorods and the organosilane of tetraethyl orthosilicate (TEOS) in an oil/water system. Multiple gold nanorods have been loaded successfully into the interior of the hierarchically porous silica nanospheres, which consist of large, interconnected pores of 13.2 nm throughout the whole sphere and small pores of 2.7 nm in the silica framework. Moreover, the loading amount (or number) of gold nanorods in the silica matrix can be tuned by simply changing the initial concentration of preformed gold nanorods. Due to the presence of the hierarchically porous structure, the PEGylated MGNRs@HPSNs display high loading capability for both small anti-tumor drugs (i.e., doxorubicin hydrochloride, 69.2 ± 7.2 mg g) and bio-macromolecules (i.e., bovine serum albumin, 248.1 ± 12.3 mg g). More importantly, MGNRs@HPSNs present better photothermal effect than that of hierarchically porous silica nanoparticles containing less (one or two) gold nanorods at the same Au concentration. It is thus demonstrated that MGNRs@HPSNs can not only act as promising drug/protein nanocarriers, but also can be used as photoabsorbers for photothermal tumor therapy under NIR laser irradiation.
基于金的纳米复合材料因其独特的光学性质以及在生物医学应用中的巨大潜力而备受关注。在此，我们报道了一种基于两亲性嵌段共聚物聚苯乙烯-b-聚（丙烯酸）（PS-b-PAA）、十六烷基三甲基溴化铵（CTAB）、金纳米棒和正硅酸四乙酯（TEOS）在油/水体系中的协同自组装，合成多重金纳米棒封装的分级多孔二氧化硅纳米球（MGNRs@HPSNs）的简单方法。多重金纳米棒已成功负载到分级多孔二氧化硅纳米球的内部，该纳米球由贯穿整个球体的13.2 nm大的相互连接的孔和二氧化硅骨架中2.7 nm的小孔组成。此外，通过简单改变预制金纳米棒的初始浓度，可以调节二氧化硅基质中金纳米棒的负载量（或数量）。由于存在分级多孔结构，聚乙二醇化的MGNRs@HPSNs对小分子抗肿瘤药物（即盐酸多柔比星，69.2±7.2 mg g）和生物大分子（即牛血清白蛋白，248.1±12.3 mg g）均显示出高负载能力。更重要的是，在相同金浓度下，MGNRs@HPSNs比含有较少（一或两个）金纳米棒的分级多孔二氧化硅纳米颗粒具有更好的光热效应。因此证明，MGNRs@HPSNs不仅可以作为有前景的药物/蛋白质纳米载体，还可以用作近红外激光照射下光热肿瘤治疗的光吸收剂。
