Lee Minchang, Lee Hansang, Vijayakameswara Rao N, Han Hwa Seung, Jeon Sangmin, Jeon Jueun, Lee Seokyung, Kwon Seunglee, Suh Yung Doug, Park Jae Hyung
School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea.
J Mater Chem B. 2017 Sep 21;5(35):7319-7327. doi: 10.1039/c7tb01099k. Epub 2017 Aug 23.
Photodynamic therapy (PDT) has been extensively investigated to treat cancer since it induces cell death through the activation of photosensitizers by light. However, its success has been hampered by the insufficient selectivity of photosensitizers to tumor tissues. In an attempt to increase the therapeutic efficacy of PDT by targeting the photosensitizer specifically to the tumor site, we prepared chlorin e6 (Ce6)-loaded gold-stabilized carboxymethyl dextran nanoparticles (Ce6-GS-CNPs). Ce6-GS-CNPs possessed highly stable nanostructures and no significant change was observed in their particle size in the presence of serum for 6 days. When Ce6-GS-CNPs were intravenously injected into tumor-bearing mice, they exhibited prolonged circulation in the body and gradually accumulated in the tumor tissue. Under laser irradiation of the tumor site which could be recognized by the near-infrared fluorescence imaging system, Ce6-GS-CNPs effectively suppressed tumor growth. Overall, Ce6-GS-CNPs might have potential as nanomedicine for image-guided photodynamic cancer therapy.
光动力疗法（PDT）自被发现可通过光激活光敏剂诱导细胞死亡以来，已被广泛研究用于治疗癌症。然而，其成效因光敏剂对肿瘤组织的选择性不足而受到阻碍。为了通过将光敏剂特异性靶向肿瘤部位来提高光动力疗法的治疗效果，我们制备了负载二氢卟吩e6（Ce6）的金稳定羧甲基葡聚糖纳米颗粒（Ce6-GS-CNPs）。Ce6-GS-CNPs具有高度稳定的纳米结构，在血清存在的情况下6天内其粒径未观察到显著变化。当将Ce6-GS-CNPs静脉注射到荷瘤小鼠体内时，它们在体内循环时间延长，并逐渐在肿瘤组织中积累。在近红外荧光成像系统可识别的肿瘤部位进行激光照射时，Ce6-GS-CNPs有效抑制了肿瘤生长。总体而言，Ce6-GS-CNPs作为用于图像引导光动力癌症治疗的纳米药物可能具有潜力。
