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体内自组装诱导金纳米颗粒的保留以增强光热肿瘤治疗

In vivo self-assembly induced retention of gold nanoparticles for enhanced photothermal tumor treatment.

作者信息

Hu Xuefeng, Yang Peipei, He Jianping, Liang Ruijie, Niu Dechao, Wang Hao, Li Yongsheng

机构信息

Lab of Low-Dimensional Materials Chemistry, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.

出版信息

J Mater Chem B. 2017 Aug 14;5(30):5931-5936. doi: 10.1039/c7tb01268c. Epub 2017 Jul 20.

DOI:10.1039/c7tb01268c
PMID:32264349
Abstract

We present a simple route to fabricate peptide modified spherical gold nanoparticles (AuNPs@Pep1/Pep2) with enhanced retention performance in tumor sites for improved photothermal treatment (PTT), which was achieved through its in vivo self-assembly triggered by matrix metalloproteinase-2 (MMP-2).

摘要

我们提出了一种简单的方法来制备肽修饰的球形金纳米颗粒（AuNPs@Pep1/Pep2），该颗粒在肿瘤部位具有增强的滞留性能，以改善光热治疗（PTT），这是通过基质金属蛋白酶-2（MMP-2）触发其体内自组装来实现的。

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