Li Yan-Hui, Guo Min, Shi Shu-Wen, Zhang Qian-Ling, Yang Shi-Ping, Liu Jin-Gang
Key Lab for Advanced Materials, School of Chemistry & Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, P. R. China.
J Mater Chem B. 2017 Oct 14;5(38):7831-7838. doi: 10.1039/c7tb02059g. Epub 2017 Sep 21.
The development of light-controlled nitric oxide (NO)-releasing nanoplatforms that are capable of specifically targeting liver cancer cell lines and delivering an optimal amount of NO can significantly affect liver cancer therapy. In this study, a multifunctional nanoplatform {N-GQDs@Ru-NO@Gal} (1) for the near-infrared (NIR) light-responsive release of NO, consisting of a NO donor (Ru-NO) and a liver-targeting galactose derivative (Gal) covalently attached to N-doped graphene quantum dots (N-GQDs), was reported. Nanoplatform 1 preferentially targeted liver cancer cells over normal cells and instantly released NO as well as exhibited a prominent photothermal effect upon NIR irradiation at 808 nm, thereby leading to efficient anti-tumor efficacy. {N-GQDs@Ru-NO@Gal} with a small size (<10 nm), good biocompatibility, and fluorescent-tracing properties represents a unique example of a multifunctional NO-releasing nanoplatform that combines photodynamic and photothermal therapies for the targeted treatment of liver cancer. Hence, the developed nanoplatform demonstrates potential for applications in NO-mediated multimodal phototherapy in the near future.
能够特异性靶向肝癌细胞系并释放适量一氧化氮（NO）的光控NO释放纳米平台的开发，可显著影响肝癌治疗。在本研究中，报道了一种用于近红外（NIR）光响应释放NO的多功能纳米平台{N-GQDs@Ru-NO@Gal}（1），它由一个NO供体（Ru-NO）和一个与氮掺杂石墨烯量子点（N-GQDs）共价连接的肝脏靶向半乳糖衍生物（Gal）组成。纳米平台1相对于正常细胞优先靶向肝癌细胞，能即时释放NO，并且在808 nm近红外照射下表现出显著的光热效应，从而导致高效的抗肿瘤效果。{N-GQDs@Ru-NO@Gal}尺寸小（<10 nm）、生物相容性好且具有荧光追踪特性，是一种独特的多功能NO释放纳米平台，它结合了光动力疗法和光热疗法用于肝癌的靶向治疗。因此，所开发的纳米平台在不久的将来显示出在NO介导的多模态光疗中的应用潜力。
