Key Lab for Advanced Materials, School of Chemistry & Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, P. R. China.
J Mater Chem B. 2019 Mar 21;7(11):1867-1874. doi: 10.1039/c8tb02743a. Epub 2019 Jan 16.
This study reports a strategy of combining a Pt(iv) prodrug and a ruthenium nitrosyl (Ru-NO) donor into a single nanoplatform {N-GQDs@Ru-NO-Pt@FA} in which the platinum(iv) prodrug is conjugated onto a photoactivatable NO donor (Ru-NO) through a covalent bond and the nitric oxide-releasing platinum prodrug and folate groups are decorated on N-doped graphene quantum dots (N-GQDs). After cellular uptake of the nanoplatform, the platinum(iv) prodrug was reduced to an active anti-cancer Pt(ii) species inside the cancerous cells, and simultaneously, near-infrared (NIR) light illumination induced the release of NO, accompanied by a prominent photothermal effect. This nanoplatform is capable of targeting intracellular co-delivery of Pt(ii) and NO under 808 nm NIR light irradiation, accompanied by photothermal therapy, thereby leading to a significant synergistic therapeutic effect.
本研究报告了一种将铂(iv)前药和钌亚硝酰基（Ru-NO）供体结合到单个纳米平台{ N-GQDs@Ru-NO-Pt@FA}中的策略，其中铂(iv)前药通过共价键连接到光活化的 NO 供体（Ru-NO）上，并且一氧化氮释放的铂前药和叶酸基团被修饰在氮掺杂石墨烯量子点（N-GQDs）上。纳米平台被细胞摄取后，铂(iv)前药在癌细胞内被还原为活性抗癌 Pt(ii)物种，同时，近红外（NIR）光照射诱导 NO 的释放，并伴随着显著的光热效应。该纳米平台能够在 808nm 近红外光照射下靶向细胞内共递送 Pt(ii)和 NO，并结合光热疗法，从而产生显著的协同治疗效果。
