Yang Meiding, Zhou Huipeng, Li Yongxin, Zhang Qingfeng, Li Juanmin, Zhang Cuiyun, Zhou Chuibei, Yu Cong
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China.
J Mater Chem B. 2017 Aug 28;5(32):6572-6578. doi: 10.1039/c7tb00212b. Epub 2017 Mar 15.
A new water soluble coronene bisimide derivative (CTDI) was designed and synthesized. CTDI self-assembled in an aqueous solution and formed supramolecular nanofibers through π-π stacking and hydrophobic interactions. The nanofibers exhibit distinct peroxidase-like catalytic activity, and can catalyze the redox reaction of 3,3,5,5-tetramethylbenzidine (TMB) in the presence of hydrogen peroxide. Clear assay solution color changes were observed. The peroxidase-like catalytic property was utilized for the sensitive detection of HO and glucose. The assay shows excellent sensitivity, and 1 μM of glucose could be easily detected. Glucose detection in dilute human blood samples was also demonstrated, and the results were verified using a commercial glucose meter. Our method is simple, convenient, sensitive and selective, and could facilitate the sensing of glucose in relation to biological and biomedical research applications.
设计并合成了一种新型水溶性蒄二酰亚胺衍生物（CTDI）。CTDI在水溶液中自组装，通过π-π堆积和疏水相互作用形成超分子纳米纤维。这些纳米纤维表现出独特的类过氧化物酶催化活性，并且在过氧化氢存在下能够催化3,3,5,5-四甲基联苯胺（TMB）的氧化还原反应。观察到测定溶液颜色有明显变化。利用这种类过氧化物酶催化特性对过氧化氢和葡萄糖进行灵敏检测。该测定方法具有出色的灵敏度，能够轻松检测到1 μM的葡萄糖。还展示了在稀释人血样本中的葡萄糖检测，并使用商用血糖仪对结果进行了验证。我们的方法简单、方便、灵敏且具有选择性，有助于在生物和生物医学研究应用中对葡萄糖进行传感检测。
