Ou Jun, Zheng Weihua, Xiao Zhiyin, Yan Yuping, Jiang Xiujuan, Dou Yong, Jiang Ran, Liu Xiaoming
College of Materials Science and Engineering, Key Laboratory of New Processing Technology for Nonferrous Materials (Ministry of Education), Collaborative Innovation Center for Exploration of Hidden Nonferrous Metal Deposits and Development of New Materials in Guangxi, Guilin University of Technology, Guilin, Guangxi 514000, China.
J Mater Chem B. 2017 Nov 7;5(41):8161-8168. doi: 10.1039/c7tb01434a. Epub 2017 Sep 27.
CO-release induced by near infrared (NIR) light, to which body tissues are relatively transparent, from photoactive CO-releasing molecules (PhotoCORMs) has great significance in exploring the clinical potential of CO. In this work, a novel upconversion nanoparticle-based nanoplatform, UCNPs@SiO-CORMs, has been developed using a one-pot reaction. The materials liberate CO under the irradiation of NIR light. TEM images of the materials showed that this nanoplatform consisted of a core-shell structure. On the surface were incorporated thiol groups through which mono-iron(ii) carbonyl units, "Fe(η-Cp)(CO)" were successfully anchored by a ligand exchange reaction between [Fe(η-Cp)(CO)I] (1) and the thiol groups. The core of the materials consists of β-NaYF:Yb/Er upconversion nanoparticles (UCNPs). Strong emission bands around 530 and 550 nm from the materials upon irradiation by NIR fall into the broad band of the electronic spectrum of the materials. Consequently, the constructed nanoplatform steadily released CO upon irradiation with a 980 nm laser (1 W cm). Kinetic analysis suggests that CO-release from UCNPs@SiO-CORMs in DMSO/DO media fits a zero-order reaction model. Assessment of the cytotoxicity of UCNPs@SiO-CORMs indicated that they showed excellent biocompatibility and no significant photo-toxicity.
由近红外（NIR）光诱导的一氧化碳释放，人体组织对其相对透明，这种来自光活性一氧化碳释放分子（光化学一氧化碳释放剂，PhotoCORMs）的一氧化碳释放对于探索一氧化碳的临床潜力具有重要意义。在这项工作中，通过一锅法反应开发了一种新型的基于上转换纳米颗粒的纳米平台UCNPs@SiO-CORMs。该材料在近红外光照射下释放一氧化碳。材料的透射电子显微镜（TEM）图像显示，这种纳米平台具有核壳结构。表面引入了硫醇基团，通过[Fe(η-Cp)(CO)I]（1）与硫醇基团之间的配体交换反应，单铁（II）羰基单元“Fe(η-Cp)(CO)”成功地锚定在表面。材料的核心由β-NaYF:Yb/Er上转换纳米颗粒（UCNPs）组成。近红外光照射下材料在530和550nm附近的强发射带落入材料电子光谱的宽带中。因此，构建的纳米平台在980nm激光（1W/cm）照射下稳定释放一氧化碳。动力学分析表明，UCNPs@SiO-CORMs在DMSO/DO介质中的一氧化碳释放符合零级反应模型。对UCNPs@SiO-CORMs细胞毒性的评估表明，它们具有优异的生物相容性且无明显光毒性。
