Allison Shelby, Ahumada Manuel, Andronic Cristina, McNeill Brian, Variola Fabio, Griffith May, Ruel Marc, Hamel Veronique, Liang Wenbin, Suuronen Erik J, Alarcon Emilio I
Division of Cardiac Surgery, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario K1Y 4W7, Canada.
J Mater Chem B. 2017 Apr 7;5(13):2402-2406. doi: 10.1039/c7tb00405b. Epub 2017 Mar 21.
We report for the first time the preparation of a fibrous material composed of surface grafted spherical nanosilver and collagen using one-step electrospinning. The resulting composite showed comparable morphology to the control without nanosilver, but had improved electrical conductivity. Under electrical stimulation, fibrous materials containing nanosilver increased connexin-43 expression and proliferation of neonatal cardiomyocytes. Furthermore, composites containing nanosilver prevented biofilm formation but did not activate macrophages.
我们首次报道了使用一步电纺丝法制备由表面接枝球形纳米银和胶原蛋白组成的纤维材料。所得复合材料的形态与不含纳米银的对照物相当，但具有更高的电导率。在电刺激下，含纳米银的纤维材料增加了连接蛋白-43的表达并促进了新生心肌细胞的增殖。此外，含纳米银的复合材料可防止生物膜形成，但不会激活巨噬细胞。
