Frankfurt Initiative for Regenerative Medicine, Experimental Orthopedics and Trauma Surgery, J.W. Goethe University, Frankfurt/Main, Germany.
Eur J Trauma Emerg Surg. 2020 Apr;46(2):231-244. doi: 10.1007/s00068-020-01324-1. Epub 2020 Feb 20.
Electrical stimulation (EStim) has been shown to promote bone healing and regeneration both in animal experiments and clinical treatments. Therefore, incorporating EStim into promising new bone tissue engineering (BTE) therapies is a logical next step. The goal of current BTE research is to develop combinations of cells, scaffolds, and chemical and physical stimuli that optimize treatment outcomes. Recent studies demonstrating EStim's positive osteogenic effects at the cellular and molecular level provide intriguing clues to the underlying mechanisms by which it promotes bone healing. In this review, we discuss results of recent in vitro and in vivo research focused on using EStim to promote bone healing and regeneration and consider possible strategies for its application to improve outcomes in BTE treatments. Technical aspects of exposing cells and tissues to EStim in in vitro and in vivo model systems are also discussed.
电刺激（EStim）已在动物实验和临床治疗中被证明可促进骨愈合和再生。因此，将 EStim 纳入有前途的新型骨组织工程（BTE）治疗中是合乎逻辑的下一步。目前 BTE 研究的目标是开发细胞、支架以及化学和物理刺激的组合，以优化治疗效果。最近的研究表明，EStim 在细胞和分子水平上具有积极的成骨作用，为其促进骨愈合的潜在机制提供了有趣的线索。在这篇综述中，我们讨论了最近专注于使用 EStim 促进骨愈合和再生的体外和体内研究结果，并考虑了将其应用于改善 BTE 治疗效果的可能策略。还讨论了在体外和体内模型系统中使细胞和组织暴露于 EStim 的技术方面。
