Department of Pediatrics, Saint Louis University School of Medicine, Saint Louis, MO 63103, USA.
Department of Surgery, Saint Louis University School of Medicine, Saint Louis, MO 63103, USA.
Exp Biol Med (Maywood). 2020 Jun;245(12):1049-1057. doi: 10.1177/1535370220915881. Epub 2020 Apr 7.
Short bowel syndrome is associated with significant comorbidities and mortality. This study is important as unlike current systems, it provides a validated piglet model which mirrors anatomical, histological, and serological characteristics observed in human SBS. This model can be used to advance knowledge into mechanistic pathways and therapeutic modalities to improve outcomes for SBS patients. This study is novel in that in addition to significant reduction in the remnant bowel and noted liver disease, we also developed a method to emulate ileocecal valve resection and described gut adaptive responses which has important clinical implications in humans.
短肠综合征与多种并发症和死亡率相关。本研究意义重大，因为与现有系统不同，它提供了一种经过验证的仔猪模型，可模拟人类 SBS 观察到的解剖学、组织学和血清学特征。该模型可用于深入了解机制途径和治疗方式，从而改善 SBS 患者的预后。本研究具有创新性，除了明显减少残留肠段和已观察到的肝病外，我们还开发了一种模拟回盲瓣切除术的方法，并描述了肠道适应性反应，这对人类具有重要的临床意义。
