13 周时诊断为 IB3 期宫颈癌，经新辅助化疗加根治性手术后成功维持妊娠 1 例。
A case of successful maintained pregnancy after neoadjuvant chemotherapy plus radical surgery for stage IB3 cervical cancer diagnosed at 13 weeks.
机构信息
The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Shanghai Key Laboratory of Embryo Orignal Diseases, Shanghai, China.
出版信息
BMC Pregnancy Childbirth. 2020 Apr 7;20(1):202. doi: 10.1186/s12884-020-02895-y.
BACKGROUND
Cervical cancer during pregnancy is rare. The management for stage IB3 during pregnancy remains unclear and challenging. We report a successful preserved pregnancy in a stage IB3 patient who was treated with neoadjuvant chemotherapy (NACT) plus radical surgery.
CASE PRESENTATION
A 36-year-old pregnant woman was diagnosed with a 5-cm-diameter stage IB3 squamous cell carcinoma of the uterine cervix at 13 gestational weeks. The patient received 5 courses of systemic chemotherapy with carboplatin and paclitaxel every 3 weeks, followed by caesarean section and radical hysterectomy. Both the mother and infant are in good general condition.
CONCLUSION
This case suggests that NACT plus radical surgery could be one method to maintain pregnancy in stage IB3 cervical cancer diagnosed as early as 13 gestational weeks.
背景
宫颈癌在孕期较为罕见。对于孕期的 IB3 期宫颈癌的处理仍不明确且极具挑战性。我们报告了一例成功保留妊娠的 IB3 期宫颈癌患者，其接受了新辅助化疗（NACT）联合根治性手术治疗。
病例介绍
一位 36 岁的孕妇在妊娠 13 周时被诊断为直径 5cm 的 IB3 期宫颈鳞癌。该患者接受了 5 个疗程的卡铂联合紫杉醇全身化疗，每 3 周 1 次，随后行剖宫产术和根治性子宫切除术。母婴一般情况良好。
结论
本病例提示，对于妊娠 13 周诊断的 IB3 期宫颈癌，NACT 联合根治性手术可能是一种保留妊娠的方法。
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