Russell H. Morgan Department of Radiology and Radiological Science, Division of Neuroradiology and Neuro-Interventional Radiology, The Johns Hopkins University School of Medicine, Baltimore, USA.
Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, USA.
J Clin Neurosci. 2020 Jun;76:219-225. doi: 10.1016/j.jocn.2020.03.048. Epub 2020 Apr 4.
Whilst surgical resection is traditionally used for the successful eradication of locally aggressive osseous tumors, it is often hazardous or unachievable, particularly in complex anatomic sites, such as the pelvis and spine. The authors present the use of microwave ablation in combination with Zoledronic acid (ZA) administration, alone and with the use of ZA-loaded polymethyl methacrylate (PMMA) to percutaneously treat unresectable bone tumors in 4 patients with giant cell tumors (GCT), multiple myeloma (MM) and breast cancer metastasis.
虽然传统上手术切除被用于成功根除局部侵袭性骨肿瘤，但在骨盆和脊柱等复杂解剖部位，手术切除往往具有危险性或无法实现。作者介绍了单独使用和联合使用唑来膦酸（ZA）负载聚甲基丙烯酸甲酯（PMMA）经皮治疗 4 例不能切除的骨肿瘤患者的微波消融治疗方法，这些患者的肿瘤分别为骨巨细胞瘤（GCT）、多发性骨髓瘤（MM）和乳腺癌转移。
