Medical Oncology Department, Vall d'Hebron University Hospital, Barcelona, Spain
Medical Oncology Department, Vall d'Hebron University Hospital, Barcelona, Spain.
BMJ Case Rep. 2020 Apr 6;13(4):e233708. doi: 10.1136/bcr-2019-233708.
Meningioma, the second most common primary tumour of the central nervous system, is classified into three different grades based on their characteristics. Each tumour grade includes different molecular subtype, growth potential, and thus, different prognosis. Grade I meningioma is the most common subtype with a benign course, in which systemic dissemination rarely occurs. We present the case of a 48-year-old male patient with a history of grade I meningioma who was referred 3 years after the initial diagnosis to our centre due to pelvic pain. Computed tomography (CT) images showed new pelvic bone lesions whose histopathological report was compatible with a grade I meningioma. Neither hormonal therapy concomitant with octreotide nor hydroxiurea treatments were effective. Very little is known about this entity's prevalence and treatment when disseminated disease occurs. Thus, we think it is important to increase the positive and negative clinical experiences in this setting.
脑膜瘤是中枢神经系统的第二大常见原发性肿瘤，根据其特征分为三个不同级别。每个肿瘤级别包括不同的分子亚型、生长潜力，因此具有不同的预后。I 级脑膜瘤是最常见的亚型，具有良性病程，很少发生全身播散。我们报告了一例 48 岁男性患者的病例，该患者有 I 级脑膜瘤病史，在初始诊断 3 年后因骨盆疼痛被转诊至我们中心。计算机断层扫描 (CT) 图像显示新的骨盆骨病变，其组织病理学报告与 I 级脑膜瘤相符。奥曲肽联合羟基脲治疗或激素治疗均无效。对于发生播散性疾病时的这种疾病的患病率和治疗方法知之甚少。因此，我们认为在这种情况下增加阳性和阴性的临床经验很重要。
