Hashimoto R, Ozaki N, Ohta T, Kasahara Y, Kaneda N, Nagatsu T
Department of Psychiatry, Nagoya University School of Medicine, Japan.
Neuropsychobiology. 1987;17(4):176-7. doi: 10.1159/000118360.
The total biopterin levels of plasma in 12 patients with depression were measured. They were elevated significantly as compared with those in normal controls. The plasma biopterin levels in 6 of 12 patients were measured both in the depressive and in the remissive phases. In the depressive phase the total biopterin levels were increased, whereas in the remission phase they did not differ from those in normal controls. Antidepressants did not affect the plasma biopterin levels. We speculate that the elevation of the plasma biopterin levels in patients with depression was related to the depressive state itself.
对12例抑郁症患者的血浆总生物蝶呤水平进行了测定。与正常对照组相比，其水平显著升高。对12例患者中的6例在抑郁期和缓解期均进行了血浆生物蝶呤水平测定。在抑郁期，总生物蝶呤水平升高，而在缓解期，其与正常对照组无差异。抗抑郁药不影响血浆生物蝶呤水平。我们推测抑郁症患者血浆生物蝶呤水平的升高与抑郁状态本身有关。
