Vallarino M, Ottonello I, D'Este L, Renda T
Istituto di Anatomia Comparata, Università di Genova, Italy.
Neurosci Lett. 1988 Dec 19;95(1-3):119-24. doi: 10.1016/0304-3940(88)90643-x.
The localization of a sauvagine (SV)/urotensin I (UI)-like material in the brain of the dogfish, Scyliorhinus canicula, was studied by immunohistochemical techniques, employing an antiserum raised in rabbit against synthetic SV which widely cross-reacts with UI. Positive cell bodies and nerve fibers were identified in the dorsocaudal hypothalamic region of the tuberculum posterius, in the nucleus sacci vasculosi and nucleus tuberculi posterioris. A dense network of immunoreactive axons was shown in the whole tuberculum posterius. These findings support the view that SV/UI-like peptides may be involved in neuromodulatory functions throughout the brain of cartilaginous fish.
利用免疫组织化学技术，采用兔抗合成鲑精蛋白（SV）的抗血清（该抗血清与尾加压素I（UI）广泛交叉反应），研究了星鲨脑中类鲑精蛋白（SV）/类尾加压素I（UI）物质的定位。在延髓后结节的背尾侧下丘脑区域、血管囊核和后结节核中鉴定出阳性细胞体和神经纤维。在整个延髓后结节中显示出密集的免疫反应性轴突网络。这些发现支持了这样一种观点，即类SV/UI肽可能参与软骨鱼类全脑的神经调节功能。
