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非瑟酮对心肌缺血/再灌注损伤的保护作用。

Protective effects of fisetin against myocardial ischemia/reperfusion injury.

作者信息

Long Lihui, Han Xuliang, Ma Xingming, Li Kai, Liu Linjie, Dong Juanni, Qin Bei, Zhang Kelin, Yang Kuan, Yan Honglin

机构信息

Department of Pharmacy, The First Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi 710077, P.R. China.

Department of Pharmacology, College of Pharmacy of Xi'an Medical University, Xi'an, Shaanxi 710061, P.R. China.

出版信息

Exp Ther Med. 2020 May;19(5):3177-3188. doi: 10.3892/etm.2020.8576. Epub 2020 Mar 6.

DOI:10.3892/etm.2020.8576
PMID:32266013
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7132235/
Abstract

The underlying mechanism of the myocardial protective effect of fisetin was studied in a rat ischemia/reperfusion injury model. Sprague-Dawley rats were randomly assigned to seven groups and pretreated with different solutions by gavage administration. A rat model of cardiac ischemia/reperfusion injury was established. Plasma levels of Von Willebrand factor (vWF) were determined by ELISA, flow cytometry was used to determine the level of cardiomyocyte apoptosis and 2,3,5-triphenyltetrazolium staining was used to determine the size of myocardial infarcts. Hematoxylin and eosin-stained sections of myocardial tissues were examined for pathological changes. Expressions of nuclear factor (NF)-κB and matrix metallopeptidase 9 (MMP-9) were measured by immunohistochemistry. Compared with the model group, rats pretreated with fisetin, quercetin and aspirin showed significant prolongation of clotting time, prothrombin time, thrombin time and activated partial thromboplastin time. Fisetin treatment better maintained the integrity of myocardial fibers and nuclear integrity, reduced the percentage of apoptotic myocardial cells, inhibited expression of NF-κB, decreased the loss of MMP-9 and reduced nuclear translocation of NF-kB. Rats pretreated with fisetin also demonstrated a significant decrease in plasma levels of vWF. In addition, the protective effect of fisetin on myocardial cells was found to be dose dependent.

摘要

在大鼠缺血/再灌注损伤模型中研究了非瑟酮心肌保护作用的潜在机制。将Sprague-Dawley大鼠随机分为七组，通过灌胃给予不同溶液进行预处理。建立心脏缺血/再灌注损伤大鼠模型。采用酶联免疫吸附测定法（ELISA）测定血浆血管性血友病因子（vWF）水平，用流式细胞术测定心肌细胞凋亡水平，用2,3,5-三苯基四氮唑染色法测定心肌梗死面积。对苏木精-伊红染色的心肌组织切片进行病理变化检查。采用免疫组织化学法检测核因子（NF）-κB和基质金属蛋白酶9（MMP-9）的表达。与模型组相比，用非瑟酮、槲皮素和阿司匹林预处理的大鼠凝血时间、凝血酶原时间、凝血酶时间和活化部分凝血活酶时间显著延长。非瑟酮治疗能更好地维持心肌纤维的完整性和细胞核的完整性，降低凋亡心肌细胞的百分比，抑制NF-κB的表达，减少MMP-9的丢失并减少NF-κB的核转位。用非瑟酮预处理的大鼠血浆vWF水平也显著降低。此外，发现非瑟酮对心肌细胞的保护作用具有剂量依赖性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb0e/7132235/493387d9fa13/etm-19-05-3177-g08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb0e/7132235/b30a30f9dba3/etm-19-05-3177-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb0e/7132235/c788e5fad3b8/etm-19-05-3177-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb0e/7132235/2e5fd34e4d06/etm-19-05-3177-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb0e/7132235/a9c781b2ecf3/etm-19-05-3177-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb0e/7132235/5bc1b8eeecec/etm-19-05-3177-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb0e/7132235/9aa0e6f51757/etm-19-05-3177-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb0e/7132235/c424a970171e/etm-19-05-3177-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb0e/7132235/61f9839c7bab/etm-19-05-3177-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb0e/7132235/493387d9fa13/etm-19-05-3177-g08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb0e/7132235/b30a30f9dba3/etm-19-05-3177-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb0e/7132235/c788e5fad3b8/etm-19-05-3177-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb0e/7132235/2e5fd34e4d06/etm-19-05-3177-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb0e/7132235/a9c781b2ecf3/etm-19-05-3177-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb0e/7132235/5bc1b8eeecec/etm-19-05-3177-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb0e/7132235/9aa0e6f51757/etm-19-05-3177-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb0e/7132235/c424a970171e/etm-19-05-3177-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb0e/7132235/61f9839c7bab/etm-19-05-3177-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb0e/7132235/493387d9fa13/etm-19-05-3177-g08.jpg

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