Alzahrani Rajab, Alrehaili Amani A, Gharib Amal F, Anjum Farah, Ismail Khadiga A, Elsawy Wael H
Department of Surgery, Medical College, Albaha University, Al Baha, Saudi Arabia.
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, Taif, Saudi Arabia.
J Cancer Prev. 2020 Mar 30;25(1):21-26. doi: 10.15430/JCP.2020.25.1.21.
Cancerous inhibitor of protein phosphatase 2A (CIP2A) has been identified as one of the most commonly altered proteins in human cancers. It blocks the tumor-suppressive action of protein phosphatase 2A (PP2A) complex and enhances malignancy. Thirty-five patients with squamous cell carcinoma of the oral cavity underwent surgical resection of the tumor. CIP2A was assessed by quantitative real-time PCR in the resected tumor tissues and in their adjacent normal tissues. CIP2A was found to be overexpressed in all oral squamous cell carcinoma (OSCC) specimens in comparison to their surrounding normal tissue. CIP2A overexpression was statistically correlated with poor prognostic feature of the tumor. Thus, a high expression level of CIP2A was associated with shorter survival. In conclusion, CIP2A is upregulated in OSCC, and its overexpression is correlated with aggressiveness of the tumor and poor outcome and survival. It may serve as a prognostic marker of OSCC.
蛋白磷酸酶2A的癌性抑制剂（CIP2A）已被确定为人类癌症中最常发生改变的蛋白质之一。它阻断蛋白磷酸酶2A（PP2A）复合物的肿瘤抑制作用并增强恶性程度。35例口腔鳞状细胞癌患者接受了肿瘤手术切除。通过定量实时PCR在切除的肿瘤组织及其相邻正常组织中评估CIP2A。与周围正常组织相比，发现CIP2A在所有口腔鳞状细胞癌（OSCC）标本中均过表达。CIP2A过表达与肿瘤的不良预后特征在统计学上相关。因此，CIP2A的高表达水平与较短的生存期相关。总之，CIP2A在OSCC中上调，其过表达与肿瘤的侵袭性、不良结局和生存期相关。它可能作为OSCC的预后标志物。
