Kaleem Mohammed, Thool Mandar, Dumore Nitin G, Abdulrahman Abdulrasheed O, Ahmad Wasim, Almostadi Amal, Alhashmi Mohammad Hassan, Kamal Mohammad Amjad, Tabrez Shams
Department of Pharmacology, Dadasaheb Balpande College of Pharmacy, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra, India.
Department of Pharmaceutics, Dadasaheb Balpande College of Pharmacy, Nagpur, Maharashtra, India.
Front Genet. 2024 Jul 26;15:1440430. doi: 10.3389/fgene.2024.1440430. eCollection 2024.
Triple-negative breast cancer (TNBC) is the most severe form of breast cancer, characterized by the loss of estrogen, progesterone, and human epidermal growth factor receptors. It is caused by various genetic and epigenetic factors, resulting in poor prognosis. Epigenetic changes, such as DNA methylation and histone modification, are the leading mechanisms responsible for TNBC progression and metastasis. This review comprehensively covers the various subtypes of TNBC and their epigenetic causes. In addition, the genetic association of TNBC with all significant genes and signaling pathways linked to the progression of this form of cancer has been enlisted. Furthermore, the possible uses of natural compounds through different mechanistic pathways have also been discussed in detail for the successful management of TNBC.
三阴性乳腺癌（TNBC）是最严重的乳腺癌形式，其特征是雌激素、孕激素和人表皮生长因子受体缺失。它由多种遗传和表观遗传因素引起，预后较差。表观遗传变化，如DNA甲基化和组蛋白修饰，是导致TNBC进展和转移的主要机制。本综述全面涵盖了TNBC的各种亚型及其表观遗传原因。此外，还列举了TNBC与所有与这种癌症进展相关的重要基因和信号通路的遗传关联。此外，还详细讨论了天然化合物通过不同作用机制途径在成功治疗TNBC方面的可能用途。
